02 Express Mis-Firing

My 02 Express, 4.3 Vortec, has an issue of mis-firing under heavey load or step hills. New Wires, plugs, Cap, Coil Etc. The Computer Scan shows DTC P1381 Misfire Detected - No Communication with Brake Control
Module Would the Brake Control Module actually cause the vehical to mis-fire and hesitate and go crazy? It flashes the check engine light while clinbing hills. Sometime works not to bad. When you leave in the morning, It barley crawls up hill kicking and bucking.
Thanks
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You need to pull history codes as well. The code indicates That it couldn't determine if the crankshaft variations were being caused by misfires or driving on a rough road surface. First an analysis of the OBDII data needs to be done. Check history for any other codes set. ABS system needs to be checked for codes. The most important part needed to troubleshoot the problem is the service manual along with an OBDII scanner.

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Could be vaccum, bad gas, low fuel pressure or bad fuel filter.

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