Bryan,
Been there many times, seen that many times. My customers always complained of a transmission shudder. If you haven't done a tune-up in a long while, then change the plugs and wires, then go from there. Ignition misfires usually happen under a load. Part throttle at cruising speed. If you lay into the throttle, the misfire goes away. Plugs and wires installed by you, are the cheapest fix.
A dishonest mechanic will sell you a trans first, and then tell you that you need spark plugs and wires.
Last week, a friend of mine, asked me to check his daughter's '95 Grand Am. It had a misfire, and a check engine light. The mechanic he took the car to said, "You need 2 fuel injectors, spark plugs, and wires", ($600). I told him to change the plugs and wires. Grand Am's didn't have many fuel injection problems, for that year.
He changed the ignition components ($60). I reset the "check engine" light, and like magic, all his troubles were gone.
You could still have a misfire, due to a bad coil. But, if those plugs and wires are old, change them first.
GMdude