The way pressure regulation is performed with fuel injection, and an electric in tank pump prevents vapor lock. The pump pumps fuel up to the fuel rail. The pressure is regulated by a valve which opens and returns fuel to the tank over a second line when the desired pressure is achieved. That, and the fact that you are dealing with a pressurized line from the tank to the fuel rail, rather than a line where you are trying to "suck" the fuel from the tank to the intake of the pump. So... BOTH conditions you mentioned - pressure and flow - are always present with fuel injection. Any fuel vapor in the line when the vehicle is turned off is instantly compressed into tiny bubbles as soon as the pump pressurizes the line when the key is turned on. Those tiny bubbles will be swept through the fuel rail, and into the return line when the pump restarts when the vehicle starts.