I've got an '01 Pathfinder with a manual transmission. I did the same 100 mile tow with my boat trailer (about 2100 pounds) four times over the four-day holiday weekend. On Saturday, the clutch slipped once, on Sunday several times, on Monday once, on Tuesday not at all. The drive is all highway, speed limits for passenger cars 55-65, mostly freeway or close to freeway. The slips were all on uphill stretches.
What's interesting is that it only slipped in fifth gear. I could absolutely stand on it in other gears, no slip. On Sunday I had to featherfoot it to keep it from slipping in fifth. Other gears were fine. But I don't see what the gear would have to do with it -- the clutch is in front of the gearbox.
I recognize that I'm probably due for a new clutch, and probably a new rear main seal (there's some oil on the bottom of the trans that's thin like 5W30 from the engine and doesn't smell like trans oil.
Chuck Tribolet