This is deja vu all over again. When the early-mid 70s energy crisis came along, some people tried disabling cylinders in search of some marginal improvement in gas mileage. That's about what they got, too, considering that the rest of the car was still the size of a river barge and showed similar concern for aerodynamics and had what we today would consider primitive engine controls and a tragicomically lossy driveline.
Later, Cadillac came out with an automated V8-6-4 scheme that earned a reputation for balky driveability; I'd imagine that most were eventually hardwired into permanent V8itude.
Chrysler, GM, and, I think, Honda have some more-sophisticated schemes on the market or in the works now. If I'm not mistaken, at least some of these schemes shuffle the cylinders that are in powered use so as to even out the wear.
Note that Honda disables one side of a vee engine, as you propose to do, but uses some pretty sophisticated additional technology (apart from the sophistication of engine controls needed to give people the driveability they want) in order to get away with that radical approach.
See for instance
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?page=3&c=y All in all: yes, you can figure out how to do the mechanical aspects; and yes, it will buy you a few to several percent in mileage; whether it's really worthwhile is up to you (and whether your engine computer will prove to be a show stopper, as mentioned by others, I dunno).
Cheers,
--Joe