What's your itinerary?
Me? Given the experiences I've had, this is the basic looking over I would give it:
1) pull oil dipstick - look for yogurt, indicative of blown intake or head gaskets. Could also look for metal particles.2) pull tranny dipstick. If fluid is black or close, or brown and not clear, I'll probably walk. Most used cars these days have brownish fluid, it's unavoidable. Needs to be clear though mostly IMHO.
3) look under car for leaks, excessive rust.4) look at coolant. One car I saw recently had green and orange coolant mixed. Gag. WATER IS A NO NO. Unless perhaps it there isn't excessive rust.
5) test drive of course. See if it shifts properly or gives any indication of a failing/slipping tranny.6) look at fluids again after driving. I don't know, seems to make sense. Once everything is mixed up.
Care to add anything? Clearly tires matter, lots of things matter. But a strong engine and tranny matters most.