F350 Transmission questions

I have a 92 2WD F350 with a 7.3L Diesel and an E40D transmission (which is the problem). My neighbor's kid has a wrecked F250 gas burner 4WD which the father wants to get out of his yard. I haven't checked yet and the father knows very little about the truck. I did look inside the cab and the shifter is the same as on my truck (with the 'knob' on the end for the OD) and the dash is the same. I don't know the 250 has the E40D transmission (but I'm hoping) but if it does I need to know a few things before I talk with the kid about money.

First is there any reason why a E40D transmission from a 4WD would not work on a 2WD?

Second how difficult is it to R/R the transmission in these trucks

Third is there any real mechanical difference between a 250 and a 350? I would think the main differences would be in the suspension system and maybe in the rear end gearing.

Also can anyone give me a hint as to what would be a fair price for the transmission alone and for the entire truck. FYI, the truck hit a tree and took out the front end and bent the frame. The father thinks the motor is shot but isn't sure. So please make a guess about it running and another for if its not. I know a running engine would make the truck worth more but a gas burner is useless to me. The interior is in fair shape but the glass is busted out so it has been exposed to the elements for quite a while (6+ months).

Well thanks for any info you can give me.

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Rich
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