My Dad has a 2000 V6 bought new. It's always run OK but never quite as good as he thought it should. Early on he had it in to the dealer and was told "All the V6's are like that."
Last week it developed a definite miss (40K miles). It was still using the original, good for 100K plugs. The diagnosis was " a fouled plug". So since they were going to replace a plug anyway he had them replace all of the plugs.
He says its running better now, stronger, smoother, better idle, then it did when it was new. Seems odd that the factory plugs were somehow "bad" from the get-go.