The door seals etc were probably once made of natural rubber. Now they're synthetic rubber - EPDM. Weather resistance is much better than natural rubber. (They still use natural rubber in tyres, along with styrene butadiene (SBR and BR) synthetic rubber, and after a few years or less the sidewall surface gets crazed and chalky and loses elasticity). Silicone oil makes it look nicer, they even use in the tyre factories for that reason. They wouldn't (or shouldn't) use "plasticiser" oils in EPDM mouldings, which would cause shrinkage / loss of elasticity when they finally evaporate or leach out, so something like silicone oil should be safe, though it might not be safe on some flexible plasticised materials, like plasticised PVC in parts not designed for exterior exposure. The same property that makes rubber molecules rubbery (double bonds) also makes rubber vulnerable to UV light. Silicone rubber was going to be the answer to that, but wasn't as good as as hoped for in practice, and usually has very poor tear resistance. The window seals on my 20+ year old truck, which is never garaged are still okay. Judging by the very black residue on the surface which cleans off on a rag, the loading of carbon black in the rubber is very high, and that carbon black is preventing UV from penetrating and damaging it further. I just use silicone oil from a spray can to clean/condition it. I don't think any "UV absorber" in some protectorant is going to make any significant difference, as you're not going to be able to get enough on and keep it there for long enough, and they are usually sacrificial and break down fast. Perhaps some anti-oxidants could help, so perhaps some proprietary products do have some small advantage. I heard that ATF is good for restoring the look of under-bonnet rubber components, but I'm not game to try it myself. I wouldn't use any oils or solvents or waxes on weather seals. EPDM is relatively very weather resistant, oxidation and ozone resistant, but not resistant to hydrocarbons. For that reason, (and to save getting it all over the paintwork) if using silicone spray, spray it on a rag and wipe it on, as if sprayed directly then it will still contain HC propellants. I know that some formulators of solvent-based "tyre shine" cut silicone oil in hydrocarbon solvent, so I'd really avoid that as well. Water based emulsions are probably okay, but IMO a bit pointless/expensive.