Zetec SE Issues

My car is a Ford Puma 1.6l Zetec-SE and I experience an issue in ignition of 2 cylinders (1 and 3). Cyliners 2 and 4 works fine. and indicator lights on
the control panel indications working issue. I have change the ignition self and the ignition wires, unsuccessfully. What can I do?
thank you in advance for response Bob
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