Ford E350 question

I have a 1994 Ford E350 460EFI (G) with a bad fuel pump. The tank is behind the rear axel. There is no way to replace the fuel pump without dropping the
tank as far as I can tell. It's a Motor Home so getting to it from the top by cutting a hole in the floor is out of the question and not enough room on top to do it without dropping the tank. My question is can an in-line fuel pump be used instead? I can get an in-line that is equal to or really better than the 45psi and 33GPH rating that Ford say's you need for this truck. It's an E350 Van chassis. Will the suction pressure in an in-line fuel pump be enough to lift the fuel out of the tank? Also can I leave the old pump in the tank as long as it's not restricted or will it interfere with fuel flow? If anyone has done this I would like to hear how it worked and what type pump you used. Thanks for you help.
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