'96 Grand Am SE Cylinder misfire

Codes? Have you already repaired the antifreeze leak?

There was an antifreeze leak a while back which was a leaking water pump. I got that replaced, now the only code that comes up is a cylinder one misfire. The engine light only comes on at certain times too

Try switching coils and see if the misfire follows the coil. You could also swap injectors and look for misfire to follow that injector. It's unusual that you have not had the manifold antifreeze leak fixed by now - assuming you have more than 25k miles on the engine.

There was a previous owner who probably had that fixed because I have never had that problem, I bought the car with 63k miles on it. I already switched coil packs and injectors and it didn't change anything, its still the 1st cylinder no matter what

Hmm... That pretty well narrows it down to bad signal to the injector, ignition module, or bad intake gasket. Try a noid light or scope on the injector. Swap ign.mod with a known good one - use plenty of elec grease.