Yes the biggest problem is the mass and drag of moving the tank around and that takes energy in the form of gas. A simple fix to try is to use
89 or 93 octane fuel as the ECM in that truck retards the spark to let it tolerate low octane fuel but in doing so it cuts power and MPG a lot at times. The only reason the knock sensor is there is so that they can put 87 in the manual because to list that it requires a higher octane fuel is a death blow to sales (even though it really needs it)