no power at full throttle
First look at the simple and cheap things, the complicated and expensive things can wait.
When was the fuel filter changed? If too long ago, replace it
Can you get any fault codes from the engine?
Sounds like a vacuum leak, particularly concerning the upshifting when you "let go of the gas" which is when the manifold vacuum is probably at its highest. I know next to nothing about this car, but I would look for a vacuum line somewhere that has become brittle or otherwise unservicable.
I second the notion of changing the fuel filter. A loss of power at speed is the first symptom. Depending on the capacity of the filter, the engine will eventually refuse to run at all.
Regards,
Ken
My 98 e320 w/ 65,000 was behaving the same way.
A new Mass Air Flow meter and, for good measure, new 02 sensors has it roaring like a tiger.
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