Synthetic tends to clean all the gunk out of your engine. Many synthetic manufacturers suggest doing a filter change at 2K miles after changing over for just this reason. I've seen synthetic do some nice cleanup work.
In _some_ older cars there is accumulated gunk keeping the seals sealed. Synthetic tends to remove this. That can be an issue for _some_ cars. Synthetic also flows a bit thinner and tends to sneak by some seals that might hold dino. Older, hardened seals which have less ability to adapt may have problems with this.
Depends. With a turbo, definitely use it. With a used car I'd do it to clean things up. With other situations, like a car bought from new, you may be right.