you know, everyone else said no, but your comment got me to thinking.....
I learned to drive on a 70-something F150 without the 4x2 on it (wasn't popular back then to boast). that was back in the 80's I now have a decrepit old 86 F150 4x2 and it definetly FEELS different. the cab seems bigger, the handling stiffer, the clearance taller. i cannot just go out and measure the differences, cause I don't have the orginal available, but it does seem different.
My guess is that frame, body, and other such things were/are for interchangability from 4x2 to 4x4. the old F150 I don't think you could have gotten in 4WD stock (aftermarket, sure) at that time. 250's and 350's i think you could have then.
just my guess, but so long ago that I could easily be wrong